Existing state-of-the-art is insufficient to solve the dust problem of domestic tablet presses
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Among the many types of tablet presses, most pharmaceutical companies prefer rotary tablet presses because it ensures both production and quality. However, similarly, many drug companies are annoyed by the fact that rotary presses always have problems with dust, drilling, and discontinuity during operation.
The tablet machine has dust problems during the tableting process. This is an urgent problem that needs to be solved. At present, domestic dust produced by high-speed rotary tablet presses and screen machines is generally used to provide vacuum suction to exclude the dust. However, due to the gap between the existing technology and awareness, the sealing effect of the equipment itself is not ideal, and some dust is still leaked to the purification area. In addition, dust generated during the process of material transfer or tablet transfer may also be directly leaked from the connection point to the decontamination area.
The problems still exist in the tablet presses used by most small and medium-sized pharmaceutical companies are that they need to be contaminated by the printer, difficult to clean, the products cannot be tested online, and the equipment operation records are filled in manually. Due to the limitations and defects of the equipment, it also brings many practical problems to the enterprise's GMP management and product quality.
One of the main reasons for the contamination of the tablet press is the unreasonable design of the lubrication system. It does not fully consider the peculiarities of the pharmaceutical equipment. A large number of equipment lubricants use liquid lubricants, combined with poor sealing, often causing drug contamination. Equipment manufacturers may consider adding time-lubricated lubricants on the tablet press or adopting reliable sealing methods to reduce or eliminate the contamination of lubricants with lubricants. Another major source of contamination is the poor sealing of feeders and rotating platforms, causing dust pollution. British MANESTY adopts a gapless feeder with a polyurethane seal ring structure so that the gap between the bottom of the feeder and the die in the turntable can achieve zero clearance, thus avoiding the defects of the current feeder in sealing.
Most home-made tablet presses are very difficult to clean and cannot be cleaned online. Not only do you need to remove the upper punch, the lower punch, and the middle mold when cleaning, but there are also many dead angles that are not easily removable and difficult to clean. Some foreign presses can achieve rapid loading and unloading and online cleaning. That is, using a small number of tools and adjusting a small number of parts can quickly and easily install and remove parts that need to be cleaned. Some tablet presses also use a changeable table for quick cleaning. Domestic tablet presses should also be improved in this regard.
The main development direction of foreign tablet presses: production under the conditions of intelligent and ultra-micro cell control and sealing. Some even used magnetic powder clutches and magnetic powder brakes and other transmission equipment, indicating that foreign presses have gone one step further.
China's tablet press makers should change the status quo of weak basic research, shortage of talents, strengthen technological upgrading and improvement of innovation mechanisms, narrow the gap with foreign products, and solve dust problems perfectly.